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Abirakast (Abiraterone 250mg) Zytiga Generic

Brand: Aprazer
Available: In stock
150 $
  • Shipping from India up to 20 days.
  • Pack of 120 tablets.
  • Manufacturer - Aprazer

Buy Abirakast (Abiraterone 250mg) Generic Zytiga at a profitable price in India

Abirakast (Abiraterone) - an inhibitor of androgen biosynthesis. In particular, abiraterone selectively inhibits the activity of the 17α-hydroxylase / C17,20-lyase (CYP17) enzyme, which is involved in androgen biosynthesis in the testes, adrenal glands, and prostate tumor cells.

CYP17 catalyzes the conversion of pregnenolone and progesterone by 17α-hydroxylation and cleavage of the C17,20 bond to testosterone precursors: dehydroepiandrosterone and androstenedione, respectively. Inhibition of CYP17 activity is also accompanied by an increase in the synthesis of mineralocorticoids in the adrenal glands.

Antiandrogen therapy, such as the use of luliberin agonists or orchiectomy, attenuates androgen synthesis in the testes, but does not affect androgen synthesis in the adrenal glands and tumors. The use of abiraterone in conjunction with luliberin agonists (or orchiectomy) reduces the serum testosterone concentration to a level below the detection threshold. Prostate-specific antigen (PSA) concentration serves as a biomarker in patients with prostate cancer.

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